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prism version 5 windows  (GraphPad Software Inc)


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    GraphPad Software Inc prism version 5 windows
    DTX-mediated ablation of Kcnip2 GlyT2 neurons (A–C) Local ablation of Kcnip2 GlyT2 neurons using AAV1.Ef1a.flex.DTA. (A) Experimental strategy. Unilateral AAV injections were made into the lumbar dorsal horn of Kcnip2 roxCre ;GlyT2::Dre;ROSA26 lsl-tdTom triple transgenic mice. (B) (Left, top) Whole-mount spinal cord after Kcnip2 GlyT2 ablation. White arrows indicate injection sites. Scale bar, 1 mm. (Middle and bottom) Loss of Kcnip2 GlyT2 neurons (red) in the dorsal horn of AAV1.Ef1a.flex.DTA injected mice. Scale bar, 100 μm. (Right) Quantification of DTA mediated loss of Kcnip2 GlyT2 neurons. n = 25 sections from five mice per group. (C) Nociceptive sensitivity and motor performance of Kcnip2 GlyT2 neuron-ablated mice, 3–4 weeks after AAV injection. n = 10 Kcnip2 GlyT2 ablated mice, and n = 12 control mice. Scale bar, 1 mm. (D–F) Spinal cord-wide ablation of Kcnip2 GlyT2 neurons. (D) Experimental strategy, i.p. injection of complete diphtheria toxin (DTX) in Kcnip2 roxCre ; GlyT2::Dre;ROSA26 lsl-iDTR triple transgenic mice. (E) Loss of tdTom ( Kcnip2 GlyT2 ) neurons in the dorsal horn of DTX treated mice. n = 9 sections from three mice per group; Scale bar, 100 μm. (F) Thermal gradient test. (Left) Time spent by Kcnip2 GlyT2 ablated and control mice in different temperature zones during a 30-min interval. (Right) Quantification of time spent in cold (13°C–22°C) and warm (28°C–39°C) zones. Median preferred temperature in Kcnip2 GlyT2 ablated (n = 7) and control mice (n = 10); ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001; <t>unpaired</t> <t>t</t> test. Mean ± SEM.
    Prism Version 5 Windows, supplied by GraphPad Software Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/unpaired+t+-test+graphpad+prism+5/prism+software/pmc09831669-433-6-9
    Average 90 stars, based on 1 article reviews
    prism version 5 windows - by Bioz Stars, 2026-11
    90/100 stars

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    1) Product Images from "Inhibitory Kcnip2 neurons of the spinal dorsal horn control behavioral sensitivity to environmental cold"

    Article Title: Inhibitory Kcnip2 neurons of the spinal dorsal horn control behavioral sensitivity to environmental cold

    Journal: Neuron

    doi: 10.1016/j.neuron.2022.10.008

    DTX-mediated ablation of Kcnip2 GlyT2 neurons (A–C) Local ablation of Kcnip2 GlyT2 neurons using AAV1.Ef1a.flex.DTA. (A) Experimental strategy. Unilateral AAV injections were made into the lumbar dorsal horn of Kcnip2 roxCre ;GlyT2::Dre;ROSA26 lsl-tdTom triple transgenic mice. (B) (Left, top) Whole-mount spinal cord after Kcnip2 GlyT2 ablation. White arrows indicate injection sites. Scale bar, 1 mm. (Middle and bottom) Loss of Kcnip2 GlyT2 neurons (red) in the dorsal horn of AAV1.Ef1a.flex.DTA injected mice. Scale bar, 100 μm. (Right) Quantification of DTA mediated loss of Kcnip2 GlyT2 neurons. n = 25 sections from five mice per group. (C) Nociceptive sensitivity and motor performance of Kcnip2 GlyT2 neuron-ablated mice, 3–4 weeks after AAV injection. n = 10 Kcnip2 GlyT2 ablated mice, and n = 12 control mice. Scale bar, 1 mm. (D–F) Spinal cord-wide ablation of Kcnip2 GlyT2 neurons. (D) Experimental strategy, i.p. injection of complete diphtheria toxin (DTX) in Kcnip2 roxCre ; GlyT2::Dre;ROSA26 lsl-iDTR triple transgenic mice. (E) Loss of tdTom ( Kcnip2 GlyT2 ) neurons in the dorsal horn of DTX treated mice. n = 9 sections from three mice per group; Scale bar, 100 μm. (F) Thermal gradient test. (Left) Time spent by Kcnip2 GlyT2 ablated and control mice in different temperature zones during a 30-min interval. (Right) Quantification of time spent in cold (13°C–22°C) and warm (28°C–39°C) zones. Median preferred temperature in Kcnip2 GlyT2 ablated (n = 7) and control mice (n = 10); ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001; unpaired t test. Mean ± SEM.
    Figure Legend Snippet: DTX-mediated ablation of Kcnip2 GlyT2 neurons (A–C) Local ablation of Kcnip2 GlyT2 neurons using AAV1.Ef1a.flex.DTA. (A) Experimental strategy. Unilateral AAV injections were made into the lumbar dorsal horn of Kcnip2 roxCre ;GlyT2::Dre;ROSA26 lsl-tdTom triple transgenic mice. (B) (Left, top) Whole-mount spinal cord after Kcnip2 GlyT2 ablation. White arrows indicate injection sites. Scale bar, 1 mm. (Middle and bottom) Loss of Kcnip2 GlyT2 neurons (red) in the dorsal horn of AAV1.Ef1a.flex.DTA injected mice. Scale bar, 100 μm. (Right) Quantification of DTA mediated loss of Kcnip2 GlyT2 neurons. n = 25 sections from five mice per group. (C) Nociceptive sensitivity and motor performance of Kcnip2 GlyT2 neuron-ablated mice, 3–4 weeks after AAV injection. n = 10 Kcnip2 GlyT2 ablated mice, and n = 12 control mice. Scale bar, 1 mm. (D–F) Spinal cord-wide ablation of Kcnip2 GlyT2 neurons. (D) Experimental strategy, i.p. injection of complete diphtheria toxin (DTX) in Kcnip2 roxCre ; GlyT2::Dre;ROSA26 lsl-iDTR triple transgenic mice. (E) Loss of tdTom ( Kcnip2 GlyT2 ) neurons in the dorsal horn of DTX treated mice. n = 9 sections from three mice per group; Scale bar, 100 μm. (F) Thermal gradient test. (Left) Time spent by Kcnip2 GlyT2 ablated and control mice in different temperature zones during a 30-min interval. (Right) Quantification of time spent in cold (13°C–22°C) and warm (28°C–39°C) zones. Median preferred temperature in Kcnip2 GlyT2 ablated (n = 7) and control mice (n = 10); ∗ p < 0.05, ∗∗ p < 0.01, ∗∗∗ p < 0.001, ∗∗∗∗ p < 0.0001; unpaired t test. Mean ± SEM.

    Techniques Used: Transgenic Assay, Injection

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    Software:

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    Analysis:

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